Description
Recombinant full-length human DRAK2 (STK17B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The DRAK2 gene accession number is NM_004226.
DRAK2 is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis (1). DRAK2 is selectively important for T-cell survival and inhibition of DRAK2 has therapeutic potential for autoimmune disease (2). T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals and deficiency of DRAK2 can affect autoimmune disease susceptibility without generalized suppression of the immune system (3)